Increased Cancer Risk: Obesity is associated with an increased risk of developing various types of cancer, including breast, colorectal, ovarian, prostate, and pancreatic cancers.
Inflammation: Chronic inflammation associated with obesity is believed to contribute to the development of cancer by creating a pro-inflammatory microenvironment that promotes tumor growth.
Insulin Resistance: Obesity is linked to insulin resistance, and elevated insulin levels may promote cell proliferation, potentially contributing to the initiation and progression of cancer.
Hormonal Factors: Obesity can alter hormonal balances, such as increased levels of estrogen and insulin-like growth factor-1 (IGF-1), which are associated with certain cancers.
Adipose Tissue and Cancer Cells: Adipose tissue, particularly visceral fat, can produce hormones and adipokines that may influence the growth and behavior of cancer cells.
Immune System Dysfunction: Obesity may impair the immune system's ability to recognize and eliminate cancer cells, potentially promoting the survival and proliferation of malignant cells.
Obesity-Related Cancers: Some cancers are specifically linked to obesity, with the International Agency for Research on Cancer recognizing obesity as a risk factor for several cancer types.
Cancer Prognosis: Obesity is associated with poorer cancer prognosis and increased mortality rates, impacting the effectiveness of cancer treatments and overall survival.